Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.36 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19367411 | 0.89 | MAP2K1 (0.43) | CSF1RMAPTMAP2K1MAP2K2MEN1 | |
| SCHEMBL15130253 | 0.88 | MAP2K1 (0.48) | MAP2K1MAP2K2BRAFMAPK1 | |
| SCHEMBL15130159 | 0.87 | NPC1 (0.43) | CSF1RMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL19366595 | 0.83 | CSF1R (0.44) | CSF1RMAP2K1MAP2K2CYP46A1MEN1 | |
| SCHEMBL19366603 | 0.83 | MAP2K1 (0.53) | MAP2K1MAP2K2 | |
| SCHEMBL19366609 | 0.82 | MAP2K1 (0.49) | CSF1RMAP2K1MAP2K2BRAFMAPK1 | |
| SCHEMBL15130261 | 0.81 | USP2 (0.41) | CSF1RMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL15130290 | 0.81 | MAP2K1 (0.45) | CSF1RMAPTMAP2K1MAP2K2ALDH1A1 | |
| SCHEMBL19367210 | 0.80 | MEN1 (0.54) | MAP2K1MAP2K2MEN1KMT2ARAF1 | |
| SCHEMBL19366605 | 0.80 | MAP2K1 (0.54) | MAP2K1MAP2K2BRAFMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9937158-B2 | Benzoheterocyclic compounds and use thereof | SHANGHAI KECHOW PHARMA, INC. (CN) | 2018-04-10 | — | — | US | disclosed |
| EP-2804855-B1 | BENZOHETEROCYCLIC COMPOUNDS AND USE THEREOF | SHANGHAI KECHOW PHARMA INC (CN) | 2017-09-20 | — | — | EP | disclosed |