Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 6/20 | 0.55 |
| ▸ | AKT1 | P31749 | 4/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1003278 | 0.72 | AKT2 (1.00) | AKT2AKT1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL1003826 | 0.69 | AKT2 (1.00) | AKT2AKT1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL5068797 | 0.64 | PIK3CD (0.71) | AKT2AKT1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22509304 | 0.64 | AKT2 (0.77) | AKT2AKT1PIK3CDPIK3CAPIK3CB | |
| Hydrochloric Acid SCHEMBL3714265 | 0.63 | PIK3CD (0.69) | AKT2AKT1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3721916 | 0.60 | PIK3CD (0.56) | AKT2AKT1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL24424256 | 0.60 | PIK3CD (0.59) | AKT2AKT1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22509291 | 0.60 | AKT2 (0.57) | AKT2AKT1NUDT1GSK3B | |
| SCHEMBL27491482 | 0.60 | PIK3CD (0.59) | AKT2AKT1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL21114462 | 0.58 | AKT2 (0.44) | AKT2AKT1PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2272517-B2 | ORTHO -CONDENSED PYRIDINE AND PYRIMIDINE DERIVATIVES (E.G. PURINES) AS PROTEIN KINASES INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2017-09-20 | — | — | EP | disclosed |