Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.71 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.71 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.71 |
| ▸ | NCF1 | P14598 | 7/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.55 |
| ▸ | AKT2 | P31751 | 2/20 | 0.53 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | HTR2B | P41595 | 4/20 | 0.47 |
| ▸ | HTR6 | P50406 | 4/20 | 0.47 |
| ▸ | HTR5A | P47898 | 2/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3714265 | 0.98 | PIK3CD (0.69) | PIK3CDPIK3CAPIK3CBNCF1ADRB2 | |
| SCHEMBL2799562 | 0.76 | AKT2 (0.67) | NCF1ADRB2AKT2NUDT1ROCK2 | |
| SCHEMBL24424256 | 0.76 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CBAKT2NUDT1 | |
| SCHEMBL27491482 | 0.76 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CBAKT2NUDT1 | |
| Hydrochloric Acid SCHEMBL2800609 | 0.75 | AKT2 (0.65) | NCF1ADRB2AKT2NUDT1ROCK2 | |
| SCHEMBL19465572 | 0.74 | PIK3CD (0.76) | PIK3CDPIK3CAPIK3CBAKT2NUDT1 | |
| SCHEMBL16882885 | 0.74 | PIK3CA (0.57) | PIK3CANCF1ADRB2AKT1HTR1A | |
| SCHEMBL3721916 | 0.74 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBAKT2NUDT1 | |
| SCHEMBL12842830 | 0.73 | HTR6 (0.58) | NCF1HTR1AHTR7HTR2BHTR6 | |
| SCHEMBL19465587 | 0.73 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBAKT2NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081817-A1 | Nitrogenous Fused Bicyclic Compound | TANABE SEIYAKU CO., LTD. (JP) | 2008-04-03 | — | — | US | disclosed |
| EP-1772454-A1 | NITROGENOUS FUSED BICYCLIC COMPOUND | TANABE SEIYAKU CO., LTD. (JP) | 2007-04-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081817-A1 | Nitrogenous Fused Bicyclic Compound | KCNH2, KCNN2, KCNN1 | PIK3CD 1984/4885PIK3CA 2075/4885PIK3CB 2392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.