SCHEMBL19370404

SCHEMBL19370404

COC(=O)c1nc2c(Br)c3sc(C(=O)OC)nc3c(Br)c2s1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.44
NPSR1 Q6W5P4 1/20 0.39
HSD17B10 Q99714 3/20 0.38
KMT2A Q03164 2/20 0.38
MAPT P10636 2/20 0.38
TSHR P16473 2/20 0.38
KDM4E B2RXH2 6/20 0.38
PKM P14618 3/20 0.38
SMN1; SMN2 Q16637 2/20 0.36
HPGD P15428 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.35
MEN1 O00255 1/20 0.35
POLB P06746 1/20 0.35
CHRM4 P08173 2/20 0.34
DYRK1A Q13627 2/20 0.33
DYRK1B Q9Y463 1/20 0.33
RCE1 Q9Y256 1/20 0.33
CES1 P23141 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19370508 0.85 ALDH1A1 (0.35) ALDH1A1KDM4EPKM
SCHEMBL31257704 0.79 KDM4E (0.39) ALDH1A1HSD17B10KMT2AMAPTKDM4E
SCHEMBL24162261 0.78 EGFR (0.36) ALDH1A1HSD17B10KMT2AKDM4EPKM
SCHEMBL19357025 0.74 ALDH1A1 (0.43) ALDH1A1HSD17B10MAPTTSHRKDM4E
SCHEMBL12894510 0.72 ALDH1A1 (0.45) ALDH1A1NPSR1HSD17B10KMT2AMAPT
SCHEMBL19224594 0.70 ALDH1A1 (0.59) ALDH1A1HSD17B10KMT2AMAPTTSHR
SCHEMBL29749248 0.70 ALDH1A1 (0.59) ALDH1A1NPSR1KMT2AMAPTTSHR
SCHEMBL28368126 0.70 ALDH1A1 (0.59) ALDH1A1NPSR1KMT2AMAPTTSHR
SCHEMBL31257722 0.70 ALDH1A1 (0.35) ALDH1A1NPSR1KMT2AMAPTTSHR
SCHEMBL18352875 0.70 CES1 (0.42) ALDH1A1NPSR1HSD17B10KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3430016-B1 ORGANIC SEMICONDUCTORS RAYNERGY TEK INC (TW) 2022-01-05 EP disclosed
WO-2017157782-A1 ORGANIC SEMICONDUCTORS MERCK PATENT GMBH (DE) 2017-09-21 WO disclosed