Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.61 |
| ▸ | BRD4 | O60885 | 3/20 | 0.57 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | IL1B | P01584 | 1/20 | 0.57 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.57 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.57 |
| ▸ | MAP1LC3B | Q9GZQ8 | 6/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19370687 | 1.00 | CRBN (0.61) | CRBNBRD4DDB1TNFIL1B | |
| SCHEMBL30937059 | 0.91 | CRBN (0.61) | CRBNBRD4DDB1TNFIL1B | |
| SCHEMBL21792617 | 0.90 | CRBN (0.59) | CRBNBRD4DDB1MAP1LC3B | |
| SCHEMBL31316521 | 0.90 | CRBN (0.65) | CRBNBRD4DDB1TNFIL1B | |
| SCHEMBL16582168 | 0.90 | MAP1LC3B (0.59) | CRBNBRD4DDB1TNFIL1B | |
| SCHEMBL25031752 | 0.90 | CRBN (0.53) | CRBNBRD4DDB1TNFIL1B | |
| SCHEMBL13643751 | 0.89 | CRBN (0.59) | CRBNBRD4DDB1MAP1LC3B | |
| SCHEMBL30772535 | 0.87 | CRBN (0.55) | CRBNBRD4DDB1TNFIL1B | |
| SCHEMBL23729386 | 0.87 | CRBN (0.72) | CRBNBRD4DDB1TNFIL1B | |
| SCHEMBL22580836 | 0.87 | CRBN (0.58) | CRBNBRD4DDB1MAP1LC3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017161119-A1 | SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC. (US) | 2017-09-21 | — | — | WO | disclosed |