Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 12/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.46 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | IL1B | P01584 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19370783 | 0.87 | DDB1 (0.47) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL19370936 | 0.85 | CRBN (0.49) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL10281239 | 0.82 | DDB1 (0.56) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL10281158 | 0.80 | CRBN (0.50) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL19359312 | 0.76 | DDB1 (0.60) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL19250991 | 0.75 | DDB1 (0.80) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL22940384 | 0.73 | CRBN (0.62) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL3797637 | 0.72 | DDB1 (0.60) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL25834823 | 0.69 | CRBN (0.58) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL19359347 | 0.69 | DDB1 (0.54) | DDB1CRBNIKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017161119-A1 | SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC. (US) | 2017-09-21 | — | — | WO | disclosed |