Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.74 |
| ▸ | KDR | P35968 | 15/20 | 0.70 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.69 |
| ▸ | CSF1R | P07333 | 1/20 | 0.67 |
| ▸ | BRAF | P15056 | 3/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.62 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.62 |
| ▸ | RAF1 | P04049 | 2/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
| ▸ | FLT1 | P17948 | 1/20 | 0.60 |
| ▸ | FLT4 | P35916 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19373292 | 0.91 | KDR (0.81) | METKDRPDGFRACSF1RBRAF | |
| SCHEMBL5202980 | 0.90 | KDR (0.85) | METKDRPDGFRACSF1RBRAF | |
| SCHEMBL29722991 | 0.89 | KDR (0.73) | METKDRPDGFRACSF1RBRAF | |
| SCHEMBL28759806 | 0.89 | KDR (0.73) | METKDRPDGFRACSF1RBRAF | |
| SCHEMBL30448368 | 0.85 | KDR (0.69) | METKDRPDGFRACSF1RBRAF | |
| SCHEMBL28979434 | 0.85 | KDR (0.69) | METKDRPDGFRACSF1RBRAF | |
| SCHEMBL371818 | 0.84 | MET (0.83) | METKDRPDGFRACSF1RKIT | |
| SCHEMBL29693477 | 0.84 | MET (0.83) | METKDRPDGFRACSF1RKIT | |
| SCHEMBL6009208 | 0.83 | KDR (0.83) | METKDRPDGFRACSF1RBRAF | |
| SCHEMBL5824482 | 0.83 | KDR (0.74) | METKDRPDGFRACSF1RPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409704-B1 | c-Met modulators and methods of use | EXELIXIS INC (US) | 2017-09-20 | — | — | EP | disclosed |