Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.61 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.41 |
| ▸ | SYK | P43405 | 9/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1937153 | 1.00 | ROCK2 (0.61) | ROCK2ROCK1MAPK8SYKMAPK9 | |
| SCHEMBL1937650 | 0.89 | ROCK2 (0.77) | ROCK2ROCK1MAPK8SYKMAPK9 | |
| SCHEMBL1937648 | 0.89 | ROCK2 (0.77) | ROCK2ROCK1MAPK8SYKMAPK9 | |
| SCHEMBL3630238 | 0.88 | ROCK2 (0.59) | ROCK2ROCK1MAPK8SYKMAPK9 | |
| SCHEMBL3627383 | 0.88 | ROCK2 (0.79) | ROCK2ROCK1MAPK8SYKMAPK9 | |
| SCHEMBL3630689 | 0.88 | ROCK2 (0.59) | ROCK2ROCK1MAPK8SYKMAPK9 | |
| SCHEMBL3630241 | 0.88 | ROCK2 (0.59) | ROCK2ROCK1MAPK8SYKMAPK9 | |
| SCHEMBL3630683 | 0.88 | ROCK2 (0.59) | ROCK2ROCK1MAPK8SYKMAPK9 | |
| SCHEMBL3627381 | 0.88 | ROCK2 (0.79) | ROCK2ROCK1MAPK8SYKMAPK9 | |
| SCHEMBL3627682 | 0.80 | GAA (0.49) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331507-A2 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | Astellas Pharma Inc. (JP) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010032875-A2 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2010-03-25 | — | — | WO | disclosed |