Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 18/20 | 0.64 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17178214 | 0.81 | PDE3B (0.50) | DRD1CNR2 | |
| SCHEMBL19390802 | 0.81 | CNR2 (0.47) | DRD1TRPA1CNR2 | |
| SCHEMBL21999457 | 0.81 | DRD1 (0.58) | DRD1TRPA1 | |
| SCHEMBL15688121 | 0.80 | DRD1 (0.62) | DRD1 | |
| SCHEMBL19371603 | 0.79 | DRD1 (0.53) | DRD1TRPA1 | |
| SCHEMBL17174341 | 0.78 | DRD1 (0.46) | DRD1TRPA1CNR2 | |
| SCHEMBL19371613 | 0.77 | DRD1 (0.58) | DRD1TRPA1 | |
| SCHEMBL15698785 | 0.76 | DRD1 (0.57) | DRD1TRPA1 | |
| SCHEMBL21626534 | 0.76 | CNR2 (0.50) | DRD1CNR2 | |
| SCHEMBL18904007 | 0.76 | CNR2 (0.50) | DRD1TRPA1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323821-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | Pfizer Inc (US) | 2018-05-23 | — | — | EP | disclosed |
| EP-2917219-B1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER (US) | 2017-09-27 | — | — | EP | disclosed |