Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 12/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | FADS1 | O60427 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17178214 | 0.84 | PDE3B (0.50) | CNR2DRD1PDE3BPDE3A | |
| SCHEMBL19371614 | 0.81 | DRD1 (0.64) | CNR2DRD1TRPA1 | |
| SCHEMBL17174341 | 0.80 | DRD1 (0.46) | CNR2DRD1PDK1HTR2CTRPA1 | |
| SCHEMBL21626534 | 0.78 | CNR2 (0.50) | CNR2DRD1PDK1HTR2CPDE3B | |
| SCHEMBL18905583 | 0.78 | CNR2 (0.50) | CNR2DRD1PDK1HTR2CTRPA1 | |
| SCHEMBL18904007 | 0.78 | CNR2 (0.50) | CNR2DRD1PDK1HTR2CTRPA1 | |
| SCHEMBL17195074 | 0.78 | CNR2 (0.49) | CNR2PDK1HTR2CPDE3BPDE3A | |
| SCHEMBL24126251 | 0.74 | CNR2 (0.47) | CNR2DRD1PDK1HTR2CTRPA1 | |
| SCHEMBL22342520 | 0.74 | CNR2 (0.47) | CNR2DRD1PDK1HTR2CPDK2 | |
| SCHEMBL18903798 | 0.74 | CNR2 (0.47) | CNR2DRD1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2917219-B1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER (US) | 2017-09-27 | — | — | EP | disclosed |