Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.62 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.62 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18834207 | 0.92 | TRPC5 (0.75) | TRPC4TRPC5TRPC1KCNH2NCOA1 | |
| SCHEMBL16076123 | 0.85 | TRPC5 (0.83) | TRPC4TRPC5TRPC1KCNH2NCOA1 | |
| SCHEMBL16076257 | 0.85 | TRPC4 (0.72) | TRPC4TRPC5TRPC1KCNH2NCOA1 | |
| SCHEMBL18021118 | 0.82 | TRPC5 (0.68) | TRPC4TRPC5TRPC1KCNH2NCOA1 | |
| SCHEMBL16076122 | 0.81 | TRPC5 (0.86) | TRPC4TRPC5TRPC1KCNH2TSHR | |
| SCHEMBL16076099 | 0.80 | TRPC5 (0.77) | TRPC4TRPC5TRPC1KCNH2NCOA1 | |
| SCHEMBL16076015 | 0.80 | TRPC5 (0.85) | TRPC4TRPC5TRPC1KCNH2TSHR | |
| SCHEMBL16028691 | 0.79 | TRPC5 (0.72) | TRPC4TRPC5TRPC1KCNH2NCOA1 | |
| SCHEMBL19375022 | 0.79 | TRPC5 (0.49) | TRPC4TRPC5TRPC1KCNH2LMNA | |
| SCHEMBL16028546 | 0.78 | TRPC5 (0.82) | TRPC4TRPC5TRPC1KCNH2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |