Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 8/20 | 0.58 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16028519 | 0.92 | TRPC5 (0.70) | TRPC5TRPC4KCNH2TRPC1SMN1; SMN2 | |
| SCHEMBL16028293 | 0.86 | TRPC5 (0.71) | TRPC5TRPC4KCNH2TRPC1SMN1; SMN2 | |
| SCHEMBL30171214 | 0.85 | TRPC5 (0.55) | TRPC5TRPC4KCNH2TRPC1SMN1; SMN2 | |
| SCHEMBL16028973 | 0.85 | TRPC5 (0.55) | TRPC5TRPC4KCNH2TRPC1SMN1; SMN2 | |
| SCHEMBL16028192 | 0.85 | TRPC5 (0.55) | TRPC5TRPC4KCNH2TRPC1SMN1; SMN2 | |
| SCHEMBL30171354 | 0.85 | TRPC5 (0.80) | TRPC5TRPC4KCNH2TRPC1SMN1; SMN2 | |
| SCHEMBL16028521 | 0.85 | TRPC5 (0.80) | TRPC5TRPC4KCNH2TRPC1SMN1; SMN2 | |
| SCHEMBL16076220 | 0.85 | TRPC5 (0.60) | TRPC5TRPC4KCNH2TRPC1SMN1; SMN2 | |
| SCHEMBL16028337 | 0.84 | TRPC5 (0.69) | TRPC5TRPC4KCNH2TRPC1SMN1; SMN2 | |
| SCHEMBL16027658 | 0.84 | TRPC5 (0.81) | TRPC5TRPC4KCNH2TRPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |