Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 7/20 | 0.71 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20431743 | 0.94 | TRPC5 (0.63) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL18834749 | 0.93 | TRPC5 (0.71) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL16027643 | 0.91 | TRPC5 (0.73) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL18834070 | 0.90 | TRPC4 (0.57) | TRPC5TRPC4KCNH2TRPC1SMN1; SMN2 | |
| SCHEMBL16028679 | 0.88 | TRPC5 (0.73) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL16028352 | 0.88 | TRPC5 (0.76) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL16028879 | 0.87 | TRPC5 (0.72) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL16028259 | 0.86 | TRPC5 (0.71) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL16028737 | 0.86 | TRPC5 (0.71) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL16076055 | 0.86 | TRPC5 (0.71) | TRPC5TRPC4KCNH2TRPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |