Sugi Predict

Sugi Predict / Compounds / SCHEMBL19377635

SCHEMBL19377635

SCHEMBL19377635

CC1(C)OB(c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)OC1(C)C

nearest known ligand 0.55

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ AXL P30530 11/20 0.55
▸ MET P08581 8/20 0.50
▸ RIPK3 Q9Y572 2/20 0.50
▸ RIPK2 O43353 1/20 0.50
▸ TYRO3 Q06418 2/20 0.49
▸ MERTK Q12866 2/20 0.49
▸ FLT3 P36888 1/20 0.47
▸ AURKB Q96GD4 1/20 0.47
▸ NPC1 O15118 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ CXCR2 P25025 1/20 0.46
▸ ABL1 P00519 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19377777 0.91 AXL (0.47) AXLMETTYRO3MERTKAURKB
SCHEMBL29626156 0.86 MET (0.56) AXLMETRIPK3RIPK2TYRO3
SCHEMBL19377723 0.86 MET (0.56) AXLMETRIPK3RIPK2TYRO3
SCHEMBL28752048 0.82 AXL (0.55) AXLMETRIPK3RIPK2TYRO3
SCHEMBL2425285 0.81 MET (0.60) AXLMETRIPK3RIPK2TYRO3
SCHEMBL19377653 0.79 AXL (0.50) AXLMETRIPK3RIPK2TYRO3
SCHEMBL13212979 0.79 AXL (0.60) AXLMETRIPK3RIPK2TYRO3
SCHEMBL16340470 0.77 MEN1 (0.63) NPC1KMT2A
SCHEMBL2420414 0.76 AXL (0.57) AXLMETRIPK3RIPK2TYRO3
SCHEMBL28558552 0.76 CA1 (0.69) NPC1KMT2ACXCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260042765-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORP (US) 2026-02-12 — — US disclosed
US-12415809-B2 Pyrrolotriazine compounds as tam inhibitors INCYTE CORPORATION (US) 2025-09-16 — — US disclosed
US-20240124463-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORPORATION 2024-04-18 — — US disclosed
EP-4321513-A2 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS Incyte Corporation (US) 2024-02-14 — — EP disclosed
EP-3436461-B1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORP (US) 2023-11-01 — — EP disclosed
US-11591338-B2 Pyrrolotriazine compounds as TAM inhibitors INCYTE CORPORATION (US) 2023-02-28 — — US disclosed
CN-114456175-A Pyrrolotriazine compounds as TAM inhibitors 因赛特公司 2022-05-10 — — CN disclosed
CN-114456176-A Pyrrolotriazine compounds as TAM inhibitors 因赛特公司 2022-05-10 — — CN disclosed
CN-109348715-B Pyrrolotriazine compounds as TAM inhibitors 因赛特公司 2021-12-31 — — CN disclosed
US-20210147430-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORPORATION 2021-05-20 — — US disclosed
US-10442810-B2 Pyrrolotriazine compounds as TAM inhibitors INCYTE CORPORATION (US) 2019-10-15 — — US disclosed
US-10442810-B2 Pyrrolotriazine compounds as TAM inhibitors INCYTE CORPORATION (US) 2019-10-15 — — US disclosed
EP-3436461-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS Incyte Corporation (US) 2019-02-06 — — EP disclosed
US-20180327412-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORPORATION 2018-11-15 — — US disclosed
US-9981975-B2 Pyrrolotriazine compounds as tam inhibitors INCYTE CORPORATION (US) 2018-05-29 — — US disclosed
US-9981975-B2 Pyrrolotriazine compounds as tam inhibitors INCYTE CORPORATION (US) 2018-05-29 — — US disclosed
WO-2017172596-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORPORATION (US) 2017-10-05 — — WO disclosed
WO-2017172596-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORPORATION (US) 2017-10-05 — — WO disclosed
US-20170275290-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORPORATION 2017-09-28 — — US disclosed
US-20170275290-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORPORATION 2017-09-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260042765-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS MAP2K2, TTK, MAP2K5 AXL 107/4885MET 27/4885RIPK3 999/4885
US-20210147430-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS MERTK, MAP3K15, MAP3K5 AXL 49/4885MET 116/4885RIPK3 428/4885
US-20180327412-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS MERTK, MAP3K15, MAP3K5 AXL 49/4885MET 116/4885RIPK3 428/4885
US-20170275290-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS MERTK, MAP3K15, MAP3K5 AXL 49/4885MET 116/4885RIPK3 428/4885
US-10442810-B2 Pyrrolotriazine compounds as TAM inhibitors MERTK, MAP3K15, MAP3K5 AXL 49/4885MET 116/4885RIPK3 428/4885
US-12415809-B2 Pyrrolotriazine compounds as tam inhibitors MERTK, MAP3K15, MAP3K5 AXL 49/4885MET 116/4885RIPK3 428/4885
US-11591338-B2 Pyrrolotriazine compounds as TAM inhibitors MERTK, MAP3K15, MAP3K5 AXL 49/4885MET 116/4885RIPK3 428/4885
US-20240124463-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS MERTK, MAP3K15, MAP3K5 AXL 49/4885MET 116/4885RIPK3 428/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.