Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 11/20 | 0.56 |
| ▸ | EPX | P11678 | 1/20 | 0.56 |
| ▸ | TPO | P07202 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19381191 | 0.85 | MPO (0.57) | MPOEPXTPOCYP3A4ADORA2A | |
| SCHEMBL19359408 | 0.83 | MPO (0.59) | MPOEPXTPOCYP3A4 | |
| SCHEMBL22423839 | 0.71 | MPO (0.72) | MPOEPXTPOCYP3A4 | |
| SCHEMBL19359413 | 0.71 | MPO (0.72) | MPOEPXTPOCYP3A4 | |
| SCHEMBL22423896 | 0.71 | MPO (0.72) | MPOEPXTPOCYP3A4 | |
| SCHEMBL19381400 | 0.70 | MPO (0.57) | MPOEPXTPOCYP3A4 | |
| SCHEMBL19381399 | 0.70 | MPO (0.62) | MPOEPXTPOCYP3A4 | |
| SCHEMBL19364096 | 0.67 | MPO (0.77) | MPOEPX | |
| SCHEMBL18620320 | 0.63 | MPO (0.59) | MPOEPXTPOCYP3A4ADORA2A | |
| SCHEMBL22406585 | 0.63 | MPO (0.59) | MPOEPXTPOCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017161145-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE AND/OR EPX | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-21 | — | — | WO | disclosed |