Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.54 |
| ▸ | PANK1 | Q8TE04 | 2/20 | 0.38 |
| ▸ | PANK3 | Q9H999 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12428376 | 0.79 | HTR6 (0.83) | HTR6 | |
| SCHEMBL12427165 | 0.70 | HTR6 (1.00) | HTR6 | |
| SCHEMBL12427516 | 0.70 | HTR6 (0.83) | HTR6 | |
| SCHEMBL19382048 | 0.69 | HTR6 (0.58) | HTR6ALDH1A1 | |
| SCHEMBL12427363 | 0.69 | HTR6 (1.00) | HTR6 | |
| SCHEMBL19382417 | 0.69 | HTR6 (0.70) | HTR6KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2304131 | 0.68 | HTR6 (0.61) | HTR6 | |
| SCHEMBL12427525 | 0.67 | HTR6 (0.86) | HTR6 | |
| SCHEMBL12427524 | 0.67 | HTR6 (1.00) | HTR6 | |
| SCHEMBL12427371 | 0.67 | HTR6 (0.83) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3020719-B1 | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF AND METHODS FOR THE PRODUCTION AND USE THEREOF | ALLA CHEM LLC (US) | 2017-09-20 | — | — | EP | disclosed |