SCHEMBL19382004

SCHEMBL19382004

CNCCc1cc(C)n2nc(NC)c(S(=O)(=O)c3ccc(F)c(Cl)c3)c2n1

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 20/20 0.74
HTR2B P41595 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12427519 0.91 HTR6 (0.77) HTR6HTR2B
SCHEMBL12428404 0.89 HTR6 (0.72) HTR6HTR2B
SCHEMBL12427079 0.89 HTR6 (0.77) HTR6HTR2B
SCHEMBL12441515 0.89 HTR6 (0.77) HTR6HTR2B
SCHEMBL12427033 0.87 HTR6 (0.74) HTR6HTR2B
SCHEMBL12441686 0.87 HTR6 (0.74) HTR6HTR2B
SCHEMBL19382113 0.87 HTR6 (0.73) HTR6HTR2B
SCHEMBL8043008 0.85 HTR6 (1.00) HTR6HTR2B
SCHEMBL19382066 0.80 HTR6 (0.78) HTR6HTR2B
SCHEMBL12428325 0.79 HTR6 (0.74) HTR6HTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3020719-B1 SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF AND METHODS FOR THE PRODUCTION AND USE THEREOF ALLA CHEM LLC (US) 2017-09-20 EP disclosed