Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TYMS | P04818 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19382116 | 0.87 | TYMS (0.40) | NPC1RAB9ASMN1; SMN2LMNANPSR1 | |
| SCHEMBL19382117 | 0.85 | TYMS (0.41) | NPC1RAB9ASMN1; SMN2LMNANPSR1 | |
| SCHEMBL19382008 | 0.79 | HTR6 (0.40) | NPC1RAB9ASMN1; SMN2LMNANPSR1 | |
| SCHEMBL19382068 | 0.79 | HTR6 (0.48) | NPC1RAB9ASMN1; SMN2LMNANPSR1 | |
| SCHEMBL19382122 | 0.78 | TYMS (0.41) | NPC1RAB9ASMN1; SMN2LMNANPSR1 | |
| SCHEMBL19381948 | 0.77 | HTR6 (0.42) | NPC1RAB9ASMN1; SMN2LMNANPSR1 | |
| SCHEMBL19382120 | 0.76 | TYMS (0.40) | NPC1RAB9ASMN1; SMN2LMNANPSR1 | |
| SCHEMBL19382065 | 0.74 | TYMS (0.42) | NPC1RAB9ASMN1; SMN2LMNANPSR1 | |
| SCHEMBL16104185 | 0.69 | HTR6 (0.49) | NPC1RAB9ASMN1; SMN2LMNANPSR1 | |
| SCHEMBL19382011 | 0.69 | MAPT (0.41) | SMN1; SMN2HTR6MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3020719-B1 | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF AND METHODS FOR THE PRODUCTION AND USE THEREOF | ALLA CHEM LLC (US) | 2017-09-20 | — | — | EP | disclosed |