Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1938581 | 1.00 | ABCG2 (0.59) | ABCG2NPC1MAPTRAB9AMAOA | |
| SCHEMBL7184897 | 0.85 | ABCG2 (0.45) | ABCG2NPC1MAPTRAB9AMAOA | |
| SCHEMBL7182842 | 0.85 | ABCG2 (0.45) | ABCG2NPC1MAPTRAB9AMAOA | |
| SCHEMBL7184890 | 0.85 | ABCG2 (0.45) | ABCG2NPC1MAPTRAB9AMAOA | |
| SCHEMBL4610668 | 0.82 | ABCG2 (0.85) | ABCG2NPC1MAPTRAB9AMAOA | |
| SCHEMBL4610666 | 0.82 | ABCG2 (0.85) | ABCG2NPC1MAPTRAB9AMAOA | |
| SCHEMBL7184568 | 0.82 | ABCG2 (0.70) | ABCG2MAPTMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL7184561 | 0.82 | ABCG2 (0.70) | ABCG2MAPTMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL1938567 | 0.79 | MAPT (0.60) | ABCG2NPC1MAPTRAB9AMAOA | |
| SCHEMBL1938570 | 0.79 | MAPT (0.60) | ABCG2NPC1MAPTRAB9AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9061984-B2 | Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-20110190325-A1 | COMPOUNDS, THEIR SYNTHESES, AND THIER USES | THE JOHNS HOPKINS UNIVERSITY | 2011-08-04 | — | — | US | disclosed |
| EP-2330906-A1 | COMPOUNDS, THEIR SYNTHESES, AND THEIR USES | University Of Louisville Research Foundation, Inc. (US) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010019861-A1 | COMPOUNDS, THEIR SYNTHESES, AND THEIR USES | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190325-A1 | COMPOUNDS, THEIR SYNTHESES, AND THIER USES | TERT, TYMS, NISCH | ABCG2 1032/4885NPC1 1044/4885MAPT 2194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.