Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | PHGDH | O43175 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 6/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23456293 | 0.85 | STS (0.49) | NOTUMPHGDHCNR1POLBLMNA | |
| SCHEMBL23217170 | 0.83 | IDO1 (0.57) | PHGDHIDO1TDO2POLBLMNA | |
| SCHEMBL6507125 | 0.83 | NOTUM (0.52) | NOTUMPHGDHCNR1POLBLMNA | |
| SCHEMBL19386229 | 0.83 | MAPT (0.46) | LMNASMN1; SMN2HTTTSHRMAPT | |
| SCHEMBL6501166 | 0.82 | NOTUM (0.51) | NOTUMPHGDHCNR1MAPTMEN1 | |
| SCHEMBL19386238 | 0.81 | LMNA (0.47) | PHGDHLMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL19386235 | 0.81 | SMN1; SMN2 (0.48) | LMNASMN1; SMN2GAAHTTTSHR | |
| SCHEMBL6497273 | 0.81 | NOTUM (0.50) | NOTUMPHGDHCNR1POLBGAA | |
| SCHEMBL19386236 | 0.80 | NOTUM (0.44) | NOTUMLMNASMN1; SMN2GAAHTT | |
| SCHEMBL23217289 | 0.80 | FFAR4 (0.55) | PHGDHIDO1TDO2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017165839-A1 | METHODS AND COMPOSITION OF 4-SUBSTITUTED BENZOYLPIPERAZINE-1-SUBSTITUTED CARBONYLS AS BETA-CATENIN/B-CELL LYMPHOMA 9 INHIBITORS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2017-09-28 | — | — | WO | disclosed |