Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28529705 | 0.90 | ALDH1A1 (0.41) | ALDH1A1MAPK1L3MBTL1LMNATDP1 | |
| SCHEMBL28529704 | 0.90 | ALDH1A1 (0.41) | ALDH1A1MAPK1L3MBTL1LMNATDP1 | |
| SCHEMBL7332893 | 0.83 | ALDH1A1 (0.56) | ALDH1A1MAPK1L3MBTL1LMNATDP1 | |
| SCHEMBL18826684 | 0.81 | ALDH1A1 (0.56) | ALDH1A1MAPK1L3MBTL1LMNATDP1 | |
| Formaldehyde SCHEMBL28511632 | 0.81 | ALDH1A1 (0.47) | ALDH1A1MAPK1L3MBTL1LMNATDP1 | |
| SCHEMBL1870004 | 0.80 | ALDH1A1 (0.63) | ALDH1A1MAPK1L3MBTL1LMNATDP1 | |
| SCHEMBL19960 | 0.80 | ALDH1A1 (0.63) | ALDH1A1MAPK1L3MBTL1LMNATDP1 | |
| Methylene Chloride SCHEMBL27426562 | 0.79 | ALDH1A1 (0.51) | ALDH1A1MAPK1L3MBTL1LMNATDP1 | |
| SCHEMBL1177836 | 0.79 | ALDH1A1 (0.73) | ALDH1A1MAPK1L3MBTL1LMNATDP1 | |
| Succinic Acid Monobenzyl Ester SCHEMBL2858793 | 0.79 | ALDH1A1 (0.58) | ALDH1A1MAPK1L3MBTL1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233889-B1 | ANTIMICROBIAL POLYMYXINS FOR TREATMENT OF BACTERIAL INFECTIONS | SHANGHAI MICURX PHARMACEUTICAL CO LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| CN-107257803-B | Polymyxin antibacterial agents for the treatment of bacterial infections | 上海盟科药业股份有限公司 | 2021-02-05 | — | — | CN | disclosed |
| US-9771394-B2 | Antimicrobial polymyxins for treatment of bacterial infections | MICURX PHARMACEUTICALS, INC. (KY) | 2017-09-26 | — | — | US | disclosed |