Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 8/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | FURIN | P09958 | 2/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24943387 | 0.95 | SIRT2 (0.42) | SIRT2SIRT1SIRT3HTTFURIN | |
| SCHEMBL17236057 | 0.93 | SIRT2 (0.42) | SIRT2SIRT1SIRT3HTTFURIN | |
| SCHEMBL14887424 | 0.93 | SIRT2 (0.42) | SIRT2SIRT1SIRT3HTTFURIN | |
| SCHEMBL19485753 | 0.93 | SIRT2 (0.44) | SIRT2SIRT1SIRT3HTTFURIN | |
| SCHEMBL16143151 | 0.93 | SIRT2 (0.42) | SIRT2SIRT1SIRT3HTTFURIN | |
| SCHEMBL19485818 | 0.93 | SIRT2 (0.44) | SIRT2SIRT1SIRT3HTTFURIN | |
| SCHEMBL19485764 | 0.92 | FURIN (0.44) | SIRT2SIRT1SIRT3HTTFURIN | |
| SCHEMBL19466410 | 0.92 | FURIN (0.44) | SIRT2SIRT1SIRT3HTTFURIN | |
| SCHEMBL19687798 | 0.91 | SIRT2 (0.42) | SIRT2SIRT1SIRT3FURINSIRT5 | |
| SCHEMBL19687799 | 0.91 | SIRT2 (0.42) | SIRT2SIRT1SIRT3FURINSIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9770519-B2 | Protein-polymer-drug conjugates | MERSANA THERAPEUTICS, INC. (US) | 2017-09-26 | — | — | US | disclosed |