Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 11/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 10/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 6/20 | 0.42 |
| ▸ | NPY1R | P25929 | 3/20 | 0.42 |
| ▸ | NPY4R | P50391 | 3/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.42 |
| ▸ | NPY2R | P49146 | 2/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | FURIN | P09958 | 1/20 | 0.40 |
| ▸ | NMT2 | O60551 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19687798 | 1.00 | SIRT2 (0.42) | SIRT2SIRT1ROCK2SIRT3NPY1R | |
| SCHEMBL21152791 | 0.94 | SIRT2 (0.49) | SIRT2SIRT1SIRT3 | |
| SCHEMBL21152621 | 0.94 | SIRT2 (0.43) | SIRT2SIRT1SIRT3NPY1RNPY4R | |
| SCHEMBL16156452 | 0.94 | SIRT2 (0.42) | SIRT2SIRT1ROCK2SIRT3NPY1R | |
| SCHEMBL14887361 | 0.93 | SIRT2 (0.42) | SIRT2SIRT1ROCK2SIRT3NPY1R | |
| SCHEMBL20153097 | 0.93 | SIRT5 (0.41) | SIRT2SIRT1SIRT3NPY1RNPY4R | |
| SCHEMBL15606204 | 0.93 | SIRT2 (0.41) | SIRT2SIRT1ROCK2SIRT3NPY1R | |
| SCHEMBL18758412 | 0.93 | SIRT5 (0.42) | SIRT2SIRT1SIRT3NPY1RNPY4R | |
| SCHEMBL25094717 | 0.92 | SIRT2 (0.42) | SIRT2SIRT1ROCK2SIRT3NPY1R | |
| SCHEMBL22643617 | 0.92 | SIRT2 (0.42) | SIRT2SIRT1ROCK2SIRT3NPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210106690-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | MERSANA THERAPEUTICS, INC. | 2021-04-15 | — | — | US | disclosed |
| US-10603386-B2 | Protein-polymer-drug conjugates | MERSANA THERAPEUTICS, INC. (US) | 2020-03-31 | — | — | US | disclosed |
| US-20180140716-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | MERSANA THERAPEUTICS, INC. | 2018-05-24 | — | — | US | disclosed |
| US-20170348424-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | MERSANA THERAPEUTICS, INC. | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348424-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | PBRM1, CLTB, BRAP | SIRT2 2534/4885SIRT1 2369/4885ROCK2 3947/4885 |
| US-20180140716-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | PBRM1, STAMBP, TSPO | SIRT2 2841/4885SIRT1 2541/4885ROCK2 2810/4885 |
| US-20210106690-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | PBRM1, CLTB, BRAP | SIRT2 2205/4885SIRT1 1989/4885ROCK2 3812/4885 |
| US-10603386-B2 | Protein-polymer-drug conjugates | PBRM1, CLTB, BRAP | SIRT2 2262/4885SIRT1 2098/4885ROCK2 3917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.