Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15116536 | 1.00 | PRCP (0.41) | PRCPMMP1MMP3MMP7CIT | |
| SCHEMBL15125109 | 0.90 | CIT (0.36) | PRCPMMP1MMP3MMP7CIT | |
| SCHEMBL15111977 | 0.82 | MMP1 (0.39) | MMP1MMP3MMP7S1PR4S1PR1 | |
| SCHEMBL19184987 | 0.81 | MMP1 (0.47) | MMP1MMP3MMP7 | |
| SCHEMBL16408060 | 0.81 | MMP1 (0.47) | MMP1MMP3MMP7 | |
| SCHEMBL15105790 | 0.80 | S1PR4 (0.36) | MMP1MMP3MMP7S1PR4S1PR1 | |
| SCHEMBL13758829 | 0.78 | SSTR3 (0.50) | MMP1MMP3MMP7NR1I2ABCB11 | |
| SCHEMBL13294146 | 0.78 | SSTR3 (0.50) | MMP1MMP3MMP7NR1I2ABCB11 | |
| SCHEMBL13758689 | 0.78 | SSTR3 (0.50) | MMP1MMP3MMP7NR1I2ABCB11 | |
| SCHEMBL18438936 | 0.77 | MMP1 (0.49) | MMP1MMP3MMP7OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019196-B1 | COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-06-06 | — | — | EP | disclosed |
| US-9770439-B2 | Hepatitis C virus inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-26 | — | — | US | disclosed |