Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22313809 | 0.86 | MEN1 (0.35) | MEN1KMT2AMAPTHTTALDH1A1 | |
| SCHEMBL20154826 | 0.82 | ALDH1A1 (0.35) | MEN1KMT2AMAPTHTTALDH1A1 | |
| SCHEMBL12644150 | 0.74 | MAPT (0.34) | MEN1KMT2AMAPTHTTALDH1A1 | |
| SCHEMBL12644893 | 0.72 | ALDH1A1 (0.35) | MEN1KMT2AMAPTHTTELANE | |
| SCHEMBL18117472 | 0.72 | KDM4E (0.38) | MEN1KMT2AMAPTHTTALDH1A1 | |
| SCHEMBL22789230 | 0.72 | ALDH1A1 (0.39) | MEN1KMT2AMAPTHTTALDH1A1 | |
| SCHEMBL12644149 | 0.71 | ALDH1A1 (0.35) | MEN1KMT2AMAPTHTTELANE | |
| SCHEMBL22789350 | 0.71 | MAPT (0.41) | MEN1KMT2AMAPTHTTALDH1A1 | |
| SCHEMBL13029606 | 0.71 | ALDH1A1 (0.38) | MEN1KMT2AMAPTHTTELANE | |
| SCHEMBL11987822 | 0.71 | MAPT (0.36) | MEN1KMT2AMAPTHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2580207-B1 | NITROGEN CONTAINING HETEROARYL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2017-09-27 | — | — | EP | disclosed |