Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.44 |
| ▸ | DRD1 | P21728 | 9/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | POLH | Q9Y253 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15667373 | 0.85 | ESR2 (0.50) | ESR1DRD1ESR2HSD17B1MEN1 | |
| SCHEMBL19390573 | 0.85 | ESR1 (0.42) | ESR1DRD1ESR2FGFR1 | |
| SCHEMBL15698827 | 0.83 | DRD1 (0.53) | DRD1 | |
| SCHEMBL19390799 | 0.78 | PIK3CD (0.49) | ESR1ESR2HSD17B1MEN1ALDH1A1 | |
| SCHEMBL17174412 | 0.77 | DRD1 (0.48) | DRD1MEN1KMT2A | |
| SCHEMBL15667386 | 0.76 | ESR1 (0.53) | ESR1DRD1ESR2MEN1ALDH1A1 | |
| SCHEMBL19390531 | 0.76 | ESR2 (0.41) | ESR1DRD1ESR2HSD17B1MEN1 | |
| SCHEMBL19390549 | 0.76 | ESR2 (0.41) | ESR1DRD1ESR2HSD17B1MEN1 | |
| SCHEMBL17200288 | 0.75 | DRD1 (0.49) | ESR1DRD1ESR2HSD17B1MEN1 | |
| SCHEMBL19390812 | 0.75 | HSD17B1 (0.44) | ESR1DRD1ESR2HSD17B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323821-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | Pfizer Inc (US) | 2018-05-23 | — | — | EP | disclosed |
| EP-2917219-B1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER (US) | 2017-09-27 | — | — | EP | disclosed |