Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15688327 | 0.88 | CYP1A1 (0.46) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL17174359 | 0.82 | DRD1 (0.40) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL15698728 | 0.82 | DRD1 (0.40) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL19390602 | 0.80 | ACHE (0.43) | MEN1ALOX12KMT2AALDH1A1LMNA | |
| SCHEMBL15688326 | 0.78 | ESR1 (0.44) | MEN1KMT2ADRD1GAA | |
| SCHEMBL15667486 | 0.76 | DRD1 (0.54) | MEN1KMT2AHPGDDRD1CRHR1 | |
| SCHEMBL15688642 | 0.74 | CYP1A1 (0.43) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL15688106 | 0.73 | DRD1 (0.81) | DRD1CNR1 | |
| SCHEMBL17200282 | 0.73 | DRD1 (0.53) | DRD1 | |
| SCHEMBL17228682 | 0.73 | DRD1 (0.54) | DRD1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2917219-B1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER (US) | 2017-09-27 | — | — | EP | disclosed |