Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 7/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.36 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.36 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | MT-CO2 | P00403 | 5/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19390662 | 0.84 | EZH2 (0.40) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19391133 | 0.83 | EZH2 (0.36) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19390952 | 0.83 | ALOX5 (0.41) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19391013 | 0.76 | EZH2 (0.41) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19390913 | 0.76 | EZH2 (0.44) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19390928 | 0.76 | ALOX5 (0.40) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19390670 | 0.75 | EZH2 (0.42) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19391189 | 0.74 | EZH2 (0.43) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19391135 | 0.74 | EZH2 (0.43) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL18744313 | 0.74 | CYP1A2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022184-B1 | SUBSTITUTED BENZENE COMPOUNDS | EPIZYME INC (US) | 2017-09-27 | — | — | EP | disclosed |