Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1938601 | 0.91 | ALDH1A1 (0.46) | KMT2AKDM4EHTTALDH1A1HPGD | |
| SCHEMBL1939518 | 0.89 | KMT2A (0.51) | KMT2AKDM4EHTTALDH1A1HPGD | |
| SCHEMBL1939290 | 0.89 | KMT2A (0.42) | KMT2AKDM4EHTTALDH1A1MAPK1 | |
| SCHEMBL1939819 | 0.85 | KDM4E (0.43) | KMT2AKDM4EHTTALDH1A1HPGD | |
| SCHEMBL1939541 | 0.84 | ALDH1A1 (0.39) | KMT2AKDM4EHTTALDH1A1HPGD | |
| SCHEMBL1939443 | 0.84 | ALDH1A1 (0.41) | KMT2AKDM4EHTTALDH1A1MAPK1 | |
| SCHEMBL1938926 | 0.84 | ALDH1A1 (0.39) | KMT2AKDM4EHTTALDH1A1MAPK1 | |
| SCHEMBL1938935 | 0.84 | ALDH1A1 (0.39) | KMT2AKDM4EHTTALDH1A1MAPK1 | |
| SCHEMBL1938936 | 0.84 | ALDH1A1 (0.39) | KMT2AKDM4EHTTALDH1A1MAPK1 | |
| SCHEMBL1939803 | 0.83 | KMT2A (0.40) | KMT2AKDM4EHTTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851225-B1 | PYRAZOLO-PYRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-06-15 | — | — | EP | claimed |