Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.56 |
| ▸ | ERBB3 | P21860 | 8/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 8/20 | 0.56 |
| ▸ | TEK | Q02763 | 8/20 | 0.56 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | SRC | P12931 | 7/20 | 0.41 |
| ▸ | RET | P07949 | 6/20 | 0.41 |
| ▸ | ABL1 | P00519 | 6/20 | 0.41 |
| ▸ | ABL2 | P42684 | 6/20 | 0.41 |
| ▸ | LCK | P06239 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | NPM1 | P06748 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1942497 | 0.88 | EGFR (0.66) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939350 | 0.85 | EGFR (0.54) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939159 | 0.81 | EGFR (0.51) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL5116426 | 0.78 | RET (0.45) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941497 | 0.77 | EGFR (0.68) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL5351174 | 0.76 | EGFR (0.67) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940578 | 0.75 | EGFR (0.47) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941272 | 0.75 | EGFR (0.65) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1942471 | 0.74 | EGFR (0.64) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL27620914 | 0.74 | EGFR (0.66) | EGFRERBB2ERBB3ERBB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |
| US-7271262-B2 | Pyrrolopyrimidine derivatives | PFIZER INC (US) | 2007-09-18 | — | — | US | disclosed |
| EP-1578751-A1 | PYRROLOPYRIMIDINE DERIVATIVES | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20050037999-A1 | Pyrrolopyrimidine derivatives | PFIZER INC | 2005-02-17 | — | — | US | disclosed |
| WO-2004056830-A1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050037999-A1 | Pyrrolopyrimidine derivatives | CCNA1, CCNT1, TP53 | EGFR 2758/4885ERBB2 2738/4885ERBB3 3091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.