Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 8/20 | 0.45 |
| ▸ | EGFR | P00533 | 11/20 | 0.44 |
| ▸ | SRC | P12931 | 7/20 | 0.44 |
| ▸ | ABL1 | P00519 | 6/20 | 0.44 |
| ▸ | ABL2 | P42684 | 5/20 | 0.44 |
| ▸ | LCK | P06239 | 4/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.43 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 5/20 | 0.43 |
| ▸ | TEK | Q02763 | 5/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | MST1R | Q04912 | 2/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5122419 | 0.84 | RET (0.61) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL19732787 | 0.81 | EGFR (0.60) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL10140510 | 0.81 | ADK (0.47) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL1939677 | 0.78 | EGFR (0.56) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL1942725 | 0.77 | ADK (0.52) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL1939761 | 0.77 | ADK (0.52) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL20351756 | 0.77 | ADK (0.53) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL16236685 | 0.76 | ADK (0.51) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL22086530 | 0.76 | ADK (0.51) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL30373169 | 0.76 | ADK (0.51) | RETEGFRSRCABL1ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435739-B2 | Substituted pyrrolopyrimidines useful in the treatment of cancer | CHEN JINSHAN | 2008-10-14 | — | — | US | disclosed |
| US-20050130994-A1 | Pyrrolopyre compounds useful in treatment of cancer | PFIZER INC | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130994-A1 | Pyrrolopyre compounds useful in treatment of cancer | TP53, CCNT1, CCNE1 | RET 298/4885EGFR 2127/4885SRC 1390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.