SCHEMBL19397222

SCHEMBL19397222

Cc1cn([C@H]2CC(O[PH](=O)O)[C@@H]([C@H](C)O)O2)c(=O)[nH]c1=O

nearest known ligand 0.51

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TK1 P04183 7/20 0.51
RNASE1 P07998 1/20 0.46
DHFR P00374 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19397221 1.00 TK1 (0.51) TK1RNASE1DHFR
SCHEMBL22912046 1.00 TK1 (0.51) TK1RNASE1DHFR
SCHEMBL22912041 1.00 TK1 (0.51) TK1RNASE1DHFR
SCHEMBL19401569 1.00 TK1 (0.51) TK1RNASE1DHFR
SCHEMBL19401568 1.00 TK1 (0.51) TK1RNASE1DHFR
SCHEMBL29967409 0.84 TK1 (0.53) TK1RNASE1DHFR
SCHEMBL29967685 0.84 TK1 (0.53) TK1RNASE1DHFR
SCHEMBL774219 0.83 TK1 (0.53) TK1RNASE1DHFR
SCHEMBL15835049 0.83 TK1 (0.53) TK1RNASE1DHFR
SCHEMBL14867212 0.82 TK1 (0.57) TK1RNASE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230183701-A1 Modified Double-Stranded RNA Agents BANK OF AMERICA, N.A. 2023-06-15 US disclosed
US-20230183701-A1 Modified Double-Stranded RNA Agents BANK OF AMERICA, N.A. 2023-06-15 US disclosed
US-11549109-B2 Modified double-stranded RNA agents ALNYLAM PHARMACEUTICALS, INC. (US) 2023-01-10 US disclosed
US-20220389424-A1 MODIFIED DOUBLE-STRANDED RNA AGENTS BANK OF AMERICA, N.A. 2022-12-08 US disclosed
US-11401517-B2 Modified double-stranded RNA agents ALNYLAM PHARMACEUTICALS, INC. (US) 2022-08-02 US disclosed
US-20220002727-A1 MODIFIED DOUBLE-STRANDED RNA AGENTS ALNYLAM PHARMACEUTICALS, INC. 2022-01-06 US disclosed
US-20210017519-A1 MODIFIED DOUBLE-STRANDED RNA AGENTS BANK OF AMERICA, N.A. 2021-01-21 US disclosed
US-20190241891-A1 MODIFIED DOUBLE-STRANDED RNA AGENTS BANK OF AMERICA, N.A. 2019-08-08 US disclosed
US-20190241893-A1 MODIFIED DOUBLE-STRANDED RNA AGENTS BANK OF AMERICA, N.A. 2019-08-08 US disclosed
US-10233448-B2 Modified double-stranded RNA agents ALNYLAM PHARMACEUTICALS, INC. (US) 2019-03-19 US disclosed
US-20170275626-A1 MODIFIED DOUBLE-STRANDED RNA AGENTS BANK OF AMERICA, N.A. 2017-09-28 US disclosed
US-20170275626-A1 MODIFIED DOUBLE-STRANDED RNA AGENTS BANK OF AMERICA, N.A. 2017-09-28 US disclosed