Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19402335 | 0.84 | PIM1 (0.43) | PIM1HRH3EGLN1JAK1TYK2 | |
| SCHEMBL17723600 | 0.82 | HRH3 (0.50) | PIM1HRH3EGLN1JAK1TYK2 | |
| Hydrochloric Acid SCHEMBL30328290 | 0.80 | PIM1 (0.42) | PIM1HRH3EGLN1CCNCCDK8 | |
| Hydrochloric Acid SCHEMBL30329435 | 0.78 | PIM1 (0.42) | PIM1HRH3EGLN1CCNCCDK8 | |
| SCHEMBL17723583 | 0.77 | ADRB2 (0.46) | PIM1HRH3EGLN1ALDH1A1CYP3A4 | |
| SCHEMBL20038370 | 0.76 | PIM1 (0.54) | PIM1EGLN1 | |
| SCHEMBL3781174 | 0.74 | SCN9A (0.40) | CYP3A4TSHR | |
| SCHEMBL17723601 | 0.73 | KCNJ1 (0.48) | PIM1HRH3EGLN1ALDH1A1CYP3A4 | |
| SCHEMBL18291199 | 0.72 | EGLN1 (0.46) | PIM1HRH3EGLN1 | |
| SCHEMBL17723439 | 0.72 | KCNJ1 (0.49) | PIM1HRH3EGLN1CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170275298-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | WUXI APPTEC (SHANGHAI) CO., LTD. (CN) | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275298-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | KCNJ11, KCNJ1, KCNJ2 | PIM1 1056/4885HRH3 1545/4885EGLN1 1891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.