Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.48 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17571720 | 0.87 | ESR1 (0.52) | ESR1ESR2PDCD1CD274KAT2B | |
| SCHEMBL19397694 | 0.78 | KDM4E (0.47) | KAT2BCYP2C9TDP1SLC6A2MAPT | |
| SCHEMBL19397714 | 0.77 | TP53 (0.43) | KAT2BMAPTDRD1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19397702 | 0.76 | SLC2A1 (0.47) | KAT2BTDP1SLC6A2CYP1A2CYP2D6 | |
| SCHEMBL19402451 | 0.76 | KAT2B (0.47) | ESR1ESR2PDCD1CD274KAT2B | |
| SCHEMBL19402428 | 0.76 | ESR1 (0.50) | ESR1ESR2PDCD1CD274KAT2B | |
| SCHEMBL19397736 | 0.75 | KAT2B (0.46) | ESR1ESR2PDCD1CD274KAT2B | |
| SCHEMBL19397688 | 0.75 | KAT2B (0.44) | KAT2BLMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL19397755 | 0.73 | KAT2B (0.46) | KAT2BTDP1MAPTALDH1A1KDM4E | |
| SCHEMBL15547247 | 0.73 | ESR1 (0.46) | ESR1ESR2PDCD1CD274KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170275289-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275289-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | HDAC10, HDAC6, HDAC1 | ESR1 4803/4885ESR2 4519/4885PDCD1 4769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.