Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19402428 | 0.85 | ESR1 (0.50) | ESR1ESR2CYP2C9TDP1SLC6A2 | |
| SCHEMBL14891094 | 0.78 | ESR1 (0.49) | ESR1ESR2CYP2C9TDP1SLC6A2 | |
| SCHEMBL2414855 | 0.77 | ESR1 (0.52) | ESR1ESR2CYP2C9TDP1SLC6A2 | |
| SCHEMBL17571720 | 0.77 | ESR1 (0.52) | ESR1ESR2CYP2C9TDP1SLC6A2 | |
| SCHEMBL19645455 | 0.76 | ESR1 (0.50) | ESR1ESR2CYP2C9TDP1SLC6A2 | |
| SCHEMBL19402465 | 0.74 | KAT2B (0.44) | ESR1ESR2CYP2C9TDP1SLC6A2 | |
| SCHEMBL19397756 | 0.73 | ESR1 (0.48) | ESR1ESR2CYP2C9TDP1SLC6A2 | |
| SCHEMBL93780 | 0.72 | ESR1 (0.57) | ESR1ESR2CYP2C9TDP1SLC6A2 | |
| SCHEMBL2566197 | 0.72 | ESR1 (0.56) | ESR1ESR2CYP2C9TDP1SLC6A2 | |
| SCHEMBL28445716 | 0.71 | ESR1 (0.46) | ESR1ESR2CYP2C9TDP1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10632195-B2 | Pharmaceutical device for electric-field assisted administration of Tapentadol and method of administering Tapentadol with same | GRUENENTHAL GMBH (DE) | 2020-04-28 | — | — | US | disclosed |
| US-20150148735-A1 | Electric-Field Assisted Administration of Tapentadol | GRUENENTHAL GMBH (DE) | 2015-05-28 | — | — | US | disclosed |
| EP-2874693-A1 | ELECTRIC-FIELD ASSISTED ADMINISTRATION OF TAPENTADOL | Grünenthal GmbH (DE) | 2015-05-27 | — | — | EP | disclosed |
| WO-2014012652-A1 | ELECTRIC-FIELD ASSISTED ADMINISTRATION OF TAPENTADOL | Grünenthal GmbH (DE) | 2014-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148735-A1 | Electric-Field Assisted Administration of Tapentadol | SLC1A1, SLC6A2, SLC9A3 | ESR1 1234/4885ESR2 887/4885CYP2C9 277/4885 |
| US-10632195-B2 | Pharmaceutical device for electric-field assisted administration of Tapentadol and method of administering Tapentadol with same | SLC6A2, SLC9A2, ATP1A2 | ESR1 1553/4885ESR2 1117/4885CYP2C9 128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.