Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 10/20 | 0.63 |
| ▸ | AXL | P30530 | 7/20 | 0.63 |
| ▸ | TYRO3 | Q06418 | 12/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19377762 | 0.90 | TYRO3 (0.70) | MERTKAXLTYRO3 | |
| SCHEMBL19398170 | 0.85 | MERTK (0.66) | MERTKAXLTYRO3 | |
| SCHEMBL19377721 | 0.84 | MERTK (0.64) | MERTKAXLTYRO3 | |
| SCHEMBL19377812 | 0.83 | MERTK (0.81) | MERTKAXLTYRO3 | |
| SCHEMBL19377619 | 0.82 | MERTK (0.68) | MERTKAXLTYRO3 | |
| SCHEMBL19377766 | 0.81 | TYRO3 (0.75) | MERTKAXLTYRO3 | |
| SCHEMBL19377638 | 0.80 | MERTK (0.54) | MERTKAXLTYRO3 | |
| SCHEMBL19377677 | 0.80 | TYRO3 (0.84) | MERTKTYRO3 | |
| SCHEMBL19398172 | 0.78 | MERTK (0.83) | MERTKAXLTYRO3 | |
| SCHEMBL16021417 | 0.78 | ACVRL1 (0.64) | MERTKAXLTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170275290-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION | 2017-09-28 | — | — | US | disclosed |
| US-20170275290-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275290-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | MERTK, MAP3K15, MAP3K5 | MERTK 1/4885AXL 49/4885TYRO3 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.