Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.68 |
| ▸ | TEK | Q02763 | 8/20 | 0.62 |
| ▸ | EGFR | P00533 | 7/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.62 |
| ▸ | ERBB3 | P21860 | 7/20 | 0.62 |
| ▸ | ERBB4 | Q15303 | 7/20 | 0.62 |
| ▸ | KDR | P35968 | 5/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940880 | 0.95 | PDGFRB (0.69) | PDGFRBTEKEGFRERBB2ERBB3 | |
| SCHEMBL1939610 | 0.93 | PDGFRB (0.79) | PDGFRBTEKEGFRERBB2ERBB3 | |
| SCHEMBL1940103 | 0.90 | PDGFRB (0.67) | PDGFRBTEKEGFRERBB2ERBB3 | |
| SCHEMBL1941403 | 0.90 | PDGFRB (0.64) | PDGFRBTEKEGFRERBB2ERBB3 | |
| SCHEMBL1941089 | 0.89 | PDGFRB (0.60) | PDGFRBTEKEGFRERBB2ERBB3 | |
| SCHEMBL1939951 | 0.89 | PDGFRB (0.67) | PDGFRBTEKEGFRERBB2ERBB3 | |
| SCHEMBL1940205 | 0.89 | TEK (0.62) | PDGFRBTEKEGFRERBB2ERBB3 | |
| SCHEMBL1939844 | 0.88 | EGFR (0.74) | PDGFRBTEKEGFRERBB2ERBB3 | |
| SCHEMBL1942915 | 0.88 | PDGFRB (0.61) | PDGFRBTEKEGFRERBB2ERBB3 | |
| SCHEMBL1939693 | 0.87 | PDGFRB (0.61) | PDGFRBTEKEGFRERBB2ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |