Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.54 |
| ▸ | ERBB3 | P21860 | 6/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 6/20 | 0.54 |
| ▸ | TEK | Q02763 | 5/20 | 0.54 |
| ▸ | NEK7 | Q8TDX7 | 12/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1941101 | 0.91 | EGFR (0.56) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941400 | 0.86 | EGFR (0.72) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941067 | 0.85 | EGFR (0.75) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939637 | 0.81 | EGFR (0.52) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940497 | 0.80 | EGFR (0.70) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940959 | 0.79 | EGFR (0.80) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1942596 | 0.79 | EGFR (0.61) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL5123156 | 0.78 | EGFR (0.79) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939626 | 0.75 | EGFR (0.70) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940585 | 0.73 | EIF2AK3 (0.51) | EGFRERBB2ERBB3ERBB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |