Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.61 |
| ▸ | ERBB3 | P21860 | 8/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 8/20 | 0.61 |
| ▸ | TEK | Q02763 | 7/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.52 |
| ▸ | NEK7 | Q8TDX7 | 9/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1941067 | 0.88 | EGFR (0.75) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940959 | 0.88 | EGFR (0.80) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941717 | 0.85 | EGFR (0.66) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940714 | 0.83 | EGFR (0.54) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941123 | 0.82 | EGFR (0.86) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941183 | 0.81 | EGFR (0.86) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940517 | 0.80 | RET (0.60) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939985 | 0.79 | EGFR (0.54) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941101 | 0.79 | EGFR (0.56) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939639 | 0.79 | EGFR (0.73) | EGFRERBB2ERBB3ERBB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |