Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.82 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.82 |
| ▸ | ERBB3 | P21860 | 9/20 | 0.82 |
| ▸ | ERBB4 | Q15303 | 9/20 | 0.82 |
| ▸ | TEK | Q02763 | 9/20 | 0.82 |
| ▸ | KDR | P35968 | 2/20 | 0.79 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 6/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | FES | P07332 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1939673 | 0.98 | EGFR (0.80) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941407 | 0.96 | EGFR (0.79) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940044 | 0.94 | EGFR (0.84) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941005 | 0.93 | EGFR (0.82) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941575 | 0.92 | EGFR (0.87) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940966 | 0.92 | EGFR (0.83) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941688 | 0.92 | EGFR (0.86) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940221 | 0.92 | EGFR (0.80) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940554 | 0.91 | EGFR (0.79) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940508 | 0.91 | EGFR (0.71) | EGFRERBB2ERBB3ERBB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |