Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.83 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.83 |
| ▸ | ERBB3 | P21860 | 9/20 | 0.83 |
| ▸ | ERBB4 | Q15303 | 9/20 | 0.83 |
| ▸ | TEK | Q02763 | 8/20 | 0.83 |
| ▸ | KDR | P35968 | 1/20 | 0.72 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 6/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | NEK7 | Q8TDX7 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1941688 | 0.94 | EGFR (0.86) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940004 | 0.92 | EGFR (0.82) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940044 | 0.91 | EGFR (0.84) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1942783 | 0.91 | EGFR (0.77) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941864 | 0.91 | EGFR (0.83) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940963 | 0.91 | EGFR (1.00) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941973 | 0.91 | EGFR (0.78) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939673 | 0.90 | EGFR (0.80) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941407 | 0.90 | EGFR (0.79) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939461 | 0.89 | EGFR (1.00) | EGFRERBB2ERBB3ERBB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |
| CN-1726218-A | Pyrrolopyrimidine derivatives | PFIZER PROD INC (US) | 2006-01-25 | — | — | CN | disclosed |