Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 8/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.48 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.42 |
| ▸ | AKT1 | P31749 | 4/20 | 0.42 |
| ▸ | MTOR | P42345 | 4/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940442 | 0.88 | EIF2AK3 (0.51) | EIF2AK3NTRK1NTRK3NTRK2PDGFRB | |
| SCHEMBL1940666 | 0.86 | EIF2AK3 (0.53) | EIF2AK3NTRK1NTRK3NTRK2PDGFRB | |
| SCHEMBL1939941 | 0.80 | PDGFRB (0.55) | EIF2AK3NTRK1NTRK3NTRK2PDGFRB | |
| SCHEMBL1941822 | 0.80 | NTRK1 (0.49) | EIF2AK3NTRK1NTRK3NTRK2PDGFRB | |
| SCHEMBL1940570 | 0.79 | PDGFRB (0.54) | EIF2AK3NTRK1NTRK3NTRK2PDGFRB | |
| SCHEMBL1939645 | 0.79 | PDGFRB (0.53) | EIF2AK3NTRK1NTRK3NTRK2PDGFRB | |
| SCHEMBL1940703 | 0.78 | EIF2AK3 (0.53) | EIF2AK3NTRK1NTRK3NTRK2PDGFRB | |
| SCHEMBL1939957 | 0.77 | PDGFRB (0.51) | EIF2AK3NTRK1NTRK3NTRK2PDGFRB | |
| SCHEMBL1941208 | 0.77 | PDGFRB (0.51) | EIF2AK3NTRK1NTRK3NTRK2PDGFRB | |
| SCHEMBL1940451 | 0.77 | PDGFRB (0.50) | EIF2AK3NTRK1NTRK3NTRK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | claimed |