Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.57 |
| ▸ | MPO | P05164 | 2/20 | 0.55 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.55 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL177039 | 1.00 | MEN1 (0.73) | MEN1KMT2ATDP1SMN1; SMN2MAOA | |
| Hydrochloric Acid SCHEMBL6897315 | 0.98 | SMN1; SMN2 (0.72) | MEN1KMT2ATDP1SMN1; SMN2MAOA | |
| Bromide SCHEMBL11864024 | 0.98 | MEN1 (0.70) | MEN1KMT2ATDP1SMN1; SMN2MAOA | |
| SCHEMBL6265883 | 0.96 | SMN1; SMN2 (0.76) | MEN1KMT2ATDP1SMN1; SMN2MAOA | |
| Alcohol SCHEMBL11200660 | 0.92 | SMN1; SMN2 (0.66) | MEN1KMT2ATDP1SMN1; SMN2MAOA | |
| SCHEMBL7986639 | 0.90 | CHRM2 (0.81) | MEN1KMT2ATDP1SMN1; SMN2MAOA | |
| Diethanolamine SCHEMBL5343789 | 0.90 | GAA (0.74) | MEN1KMT2ATDP1SMN1; SMN2MAOA | |
| N-Benzylmethylamine SCHEMBL781748 | 0.90 | MAPT (0.63) | MEN1KMT2ATDP1SMN1; SMN2MAOA | |
| Sulfuric Acid SCHEMBL28861186 | 0.90 | MEN1 (0.59) | MEN1KMT2ATDP1SMN1; SMN2MAOA | |
| SCHEMBL8029016 | 0.90 | CHRM2 (0.81) | MEN1KMT2ATDP1SMN1; SMN2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253534-A1 | COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS | CHINA NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH CO., LTD (CN) | 2021-08-19 | — | — | US | disclosed |
| EP-3065738-B1 | COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS | NOVARTIS AG (CH) | 2018-02-28 | — | — | EP | disclosed |
| US-20170275256-A1 | COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC., DBA THE GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253534-A1 | COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS | NR1H4, GPBAR1, SLC10A1 | MEN1 2907/4885KMT2A 4283/4885TDP1 4821/4885 |
| US-20170275256-A1 | COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS | NR1H4, GPBAR1, SLC10A1 | MEN1 2907/4885KMT2A 4283/4885TDP1 4821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.