Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.58 |
| ▸ | ERBB3 | P21860 | 7/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 7/20 | 0.58 |
| ▸ | TEK | Q02763 | 6/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940561 | 0.87 | TEK (0.60) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941056 | 0.86 | EGFR (0.61) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941729 | 0.86 | EGFR (0.60) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939355 | 0.86 | EGFR (0.77) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940944 | 0.85 | EGFR (0.79) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940603 | 0.85 | EGFR (0.64) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940247 | 0.84 | PDGFRB (0.71) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940842 | 0.84 | EGFR (0.77) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940556 | 0.84 | EGFR (0.80) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940713 | 0.83 | EGFR (0.74) | EGFRERBB2ERBB3ERBB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |
| CN-1726218-A | Pyrrolopyrimidine derivatives | PFIZER PROD INC (US) | 2006-01-25 | — | — | CN | disclosed |