Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 12/20 | 0.60 |
| ▸ | EGFR | P00533 | 8/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.60 |
| ▸ | ERBB3 | P21860 | 7/20 | 0.60 |
| ▸ | ERBB4 | Q15303 | 7/20 | 0.60 |
| ▸ | KDR | P35968 | 11/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.55 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.49 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.46 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.46 |
| ▸ | HIPK4 | Q8NE63 | 4/20 | 0.46 |
| ▸ | SLK | Q9H2G2 | 4/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.46 |
| ▸ | PLK4 | O00444 | 3/20 | 0.46 |
| ▸ | AXL | P30530 | 3/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1941309 | 0.91 | EGFR (0.54) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1940283 | 0.91 | EGFR (0.75) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1941729 | 0.89 | EGFR (0.60) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1940603 | 0.88 | EGFR (0.64) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1939937 | 0.88 | EGFR (0.58) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1940135 | 0.87 | EGFR (0.58) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1940713 | 0.86 | EGFR (0.74) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1940205 | 0.84 | TEK (0.62) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1939673 | 0.84 | EGFR (0.80) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1940004 | 0.84 | EGFR (0.82) | TEKEGFRERBB2ERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |