Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 5/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19402116 | 0.78 | IDH1 (0.47) | CYP17A1TRPV1RPS6KA5 | |
| SCHEMBL23019862 | 0.74 | LCK (0.40) | CYP17A1TRPV1RPS6KA5 | |
| SCHEMBL20956371 | 0.74 | TRPV1 (0.41) | CYP17A1TRPV1RPS6KA5 | |
| SCHEMBL17600999 | 0.74 | IDH1 (0.45) | TRPV1RPS6KA5 | |
| SCHEMBL16424016 | 0.72 | IDH1 (0.49) | CYP17A1TRPV1RPS6KA5 | |
| SCHEMBL20676930 | 0.71 | MTOR (0.42) | — | |
| SCHEMBL19402227 | 0.71 | MTOR (0.42) | — | |
| SCHEMBL16098462 | 0.70 | IDH1 (0.48) | TRPV1RPS6KA5 | |
| SCHEMBL14846877 | 0.69 | IDH1 (0.48) | TRPV1 | |
| SCHEMBL20685722 | 0.69 | SORD (0.37) | CYP17A1TRPV1RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3434674-B1 | ((4-(2-OXOIMIDAZOLIDINE-1-YL)PYRIMIDIN-2-YL)AMINE DERIVATIVES AS MUTANT IDH INHIBITORS FOR TREATING CANCER | SHANGHAI HAIHE PHARMACEUTICAL CO LTD (CN) | 2021-02-24 | — | — | EP | disclosed |
| EP-3434674-A1 | COMPOUND HAVING MUTANT IDH INHIBITORY ACTIVITY, PREPARATION METHOD AND USE THEREOF | Shanghai Haihe Pharmaceutical Co., Ltd. (CN) | 2019-01-30 | — | — | EP | disclosed |
| WO-2017162133-A1 | COMPOUND HAVING MUTANT IDH INHIBITORY ACTIVITY, PREPARATION METHOD AND USE THEREOF | 上海海和药物研究开发有限公司 | 2017-09-28 | — | — | WO | disclosed |