Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940067 | 0.93 | MAPT (0.38) | MAPTLMNAPOLBTP53ALDH1A1 | |
| SCHEMBL1939822 | 0.91 | ALDH1A1 (0.39) | MAPTLMNAPOLBALDH1A1KMT2A | |
| SCHEMBL1939720 | 0.89 | POLB (0.49) | MAPTLMNAPOLBTP53ALDH1A1 | |
| SCHEMBL1938878 | 0.87 | MAPT (0.39) | MAPTLMNAPOLBTP53ALDH1A1 | |
| SCHEMBL1938582 | 0.87 | MAPT (0.39) | MAPTLMNAPOLBTP53ALDH1A1 | |
| SCHEMBL1938895 | 0.87 | MAPT (0.39) | MAPTLMNAPOLBTP53ALDH1A1 | |
| SCHEMBL1939617 | 0.87 | TP53 (0.40) | MAPTLMNAPOLBTP53ALDH1A1 | |
| SCHEMBL1939437 | 0.86 | MAPT (0.39) | MAPTLMNAPOLBTP53ALDH1A1 | |
| SCHEMBL1939803 | 0.85 | KMT2A (0.40) | MAPTLMNAPOLBTP53ALDH1A1 | |
| SCHEMBL1938596 | 0.84 | ALDH1A1 (0.38) | MAPTLMNAPOLBALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851225-B1 | PYRAZOLO-PYRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-06-15 | — | — | EP | claimed |