Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.75 |
| ▸ | TEK | Q02763 | 11/20 | 0.75 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.75 |
| ▸ | ERBB3 | P21860 | 9/20 | 0.75 |
| ▸ | ERBB4 | Q15303 | 9/20 | 0.75 |
| ▸ | KDR | P35968 | 4/20 | 0.62 |
| ▸ | RET | P07949 | 4/20 | 0.51 |
| ▸ | SRC | P12931 | 5/20 | 0.48 |
| ▸ | ABL1 | P00519 | 4/20 | 0.48 |
| ▸ | ABL2 | P42684 | 4/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 3/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | NPM1 | P06748 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1939438 | 0.95 | EGFR (0.79) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL1941275 | 0.94 | EGFR (0.74) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL1941308 | 0.92 | TEK (0.72) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL1940879 | 0.91 | EGFR (0.81) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL1940006 | 0.91 | EGFR (0.76) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL1939508 | 0.91 | EGFR (0.76) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL1941017 | 0.91 | EGFR (0.76) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL1941499 | 0.91 | EGFR (0.75) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL1940005 | 0.90 | EGFR (0.74) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL1940307 | 0.89 | EGFR (0.75) | EGFRTEKERBB2ERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |