Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 12/20 | 0.72 |
| ▸ | EGFR | P00533 | 9/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.72 |
| ▸ | ERBB3 | P21860 | 8/20 | 0.72 |
| ▸ | ERBB4 | Q15303 | 8/20 | 0.72 |
| ▸ | RET | P07949 | 1/20 | 0.63 |
| ▸ | KDR | P35968 | 5/20 | 0.59 |
| ▸ | LCK | P06239 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | RGS12 | O14924 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1941270 | 0.95 | TEK (0.71) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1941176 | 0.94 | TEK (0.70) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1939438 | 0.93 | EGFR (0.79) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1941074 | 0.93 | TEK (0.66) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1942104 | 0.92 | EGFR (0.73) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1940346 | 0.92 | EGFR (0.75) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1942829 | 0.90 | EGFR (0.72) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1940005 | 0.89 | EGFR (0.74) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1940006 | 0.89 | EGFR (0.76) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1940879 | 0.89 | EGFR (0.81) | TEKEGFRERBB2ERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |