Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WHR1 | P49842 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAT2A | P31153 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27117202 | 0.90 | WHR1 (0.53) | WHR1KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL1941112 | 0.87 | WHR1 (0.60) | WHR1KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL27117037 | 0.87 | WHR1 (0.71) | WHR1KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL1941739 | 0.85 | PDGFRB (0.50) | WHR1KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL6779398 | 0.83 | PDE4A (0.56) | WHR1MAPTADORA2ATP53EGFR | |
| SCHEMBL27777423 | 0.81 | EGFR (0.47) | WHR1KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL295421 | 0.81 | WHR1 (0.52) | WHR1KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL1941684 | 0.81 | WHR1 (0.52) | WHR1KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL1942127 | 0.79 | WHR1 (0.53) | WHR1KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL1942856 | 0.79 | WHR1 (0.56) | WHR1KDM4EALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1052254-B1 | NITROGENOUS HETEROCYCLIC DERIVATIVES AND MEDICINE THEREOF | EISAI R&D MAN CO LTD (JP) | 2011-06-15 | — | — | EP | disclosed |
| US-6800644-B2 | PHOSPHODIESTERASE-4 INHIBITOR, AMINOQUINOLINE OR AMINOISOQUINOLINE DERIVATIVES | EISAI CO., LTD. (JP) | 2004-10-05 | — | — | US | disclosed |
| US-20020055516-A1 | Nitrogen-containing heterocyclic compounds and medicaments containing the compounds | EISAI CO., LTD. | 2002-05-09 | — | — | US | disclosed |
| US-6352989-B1 | ENZYME INHIBITORS FOR PHOSPHODIESTERASE | EISAI CO., LTD. (JP) | 2002-03-05 | — | — | US | disclosed |
| EP-1052254-A1 | NITROGENOUS HETEROCYCLIC DERIVATIVES AND MEDICINE THEREOF | Eisai Co., Ltd. (JP) | 2000-11-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020055516-A1 | Nitrogen-containing heterocyclic compounds and medicaments containing the compounds | PDE4A, PDE4B, PDE5A | WHR1 3881/4885KDM4E 612/4885ALDH1A1 952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.